Tag Archive: Ebola

Dec
07

Getting to an in vivo active compound

Its been an incredibly fast paced year and hence my posting frequency has suffered. Perhaps its time to get back to writing . Today we had a press release with SRI so that triggered me to fill in the back story. Rewind back to 2014 and the Ebola outbreak was in full flow – see …

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Nov
10

Antimalarial being tested as possible Ebola virus drug -project started with a tweet

Today we announced a new R21 grant from NCATS NIH awarded to Collaborations Pharmaceuticals, Inc andTexas Biomedical Research Institute. This continues the work published in F1000Research . What is missing from the press release and papers etc. is the back story. Why are we working on this and how did it start. Essentially it took …

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Jan
06

Select antimalarials saved lives of those infected with Ebola Virus

Lets start 2016 with a bang. Frequent Ebola collaborator Dr. Megan Coffee just pointed me to a new article in the New England Journal of Medicine that showed a ‘natural experiment’ of how fewer Ebola patients died if treated with artesunate-amodiaquine compared with artemether-lumefantrine. This is fascinating because it goes some way to verify work …

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Oct
20

Collaboration to find compounds active against Ebola

Our latest contribution to the Ebola literature came out today. A collaboration with Peter Madrid (SRI International), Robert Davey and Manu Anantpadma (Texas Biomedical Research Institute), Alex Clark (Molecular Materials Informatics) and Joel Freundlich (Rutgers). Last year I posted a few times on Ebola here, hereĀ  here and here. This interest all stemmed from some …

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Oct
23

Underwhelming big pharma response to Ebola – I urge more collaboration

A few weeks ago I asked where are the big pharma companies who have been largely surprisingly quiet during the Ebola epidemic. Today I see a press release announcing J&J will have their vaccine next year and GSK later this year. Possibly other companies will be involved at the WHO’s urging. What took so long? …

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Oct
20

In response to the NIH director

I just found a post by Dr. Antony Fauci and Dr. Francis Collins on Ebola. So I have added my 2 cents – lets see if it gets accepted and a response from some moderator (..Tax dollars well spent – who would want that job responding to folks like me). There are plenty of smart …

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Oct
02

A pharmacophore for compounds active against Ebola

I was looking through Pubmed yesterday looking for repurposing efforts applied to Ebola and found the paper by Madrid et al. This described many hits, including chloroquine and amodiaquine. Then I was tweeting with@DokteCoffee last night and she suggested another paper by Johansen et al., which described SERMs such as clomifene andĀ  toremifene. Interestingly Madrid …

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