Tag Archive: Ebola

Nov
10

Antimalarial being tested as possible Ebola virus drug -project started with a tweet

Today we announced a new R21 grant from NCATS NIH awarded to Collaborations Pharmaceuticals, Inc andTexas Biomedical Research Institute. This continues the work published in F1000Research . What is missing from the press release and papers etc. is the back story. Why are we working on this and how did it start. Essentially it took …

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Jan
06

Select antimalarials saved lives of those infected with Ebola Virus

Lets start 2016 with a bang. Frequent Ebola collaborator Dr. Megan Coffee just pointed me to a new article in the New England Journal of Medicine that showed a ‘natural experiment’ of how fewer Ebola patients died if treated with artesunate-amodiaquine compared with artemether-lumefantrine. This is fascinating because it goes some way to verify work …

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Oct
20

Collaboration to find compounds active against Ebola

Our latest contribution to the Ebola literature came out today. A collaboration with Peter Madrid (SRI International), Robert Davey and Manu Anantpadma (Texas Biomedical Research Institute), Alex Clark (Molecular Materials Informatics) and Joel Freundlich (Rutgers). Last year I posted a few times on Ebola here, hereĀ  here and here. This interest all stemmed from some …

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Oct
23

Underwhelming big pharma response to Ebola – I urge more collaboration

A few weeks ago I asked where are the big pharma companies who have been largely surprisingly quiet during the Ebola epidemic. Today I see a press release announcing J&J will have their vaccine next year and GSK later this year. Possibly other companies will be involved at the WHO’s urging. What took so long? …

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Oct
20

In response to the NIH director

I just found a post by Dr. Antony Fauci and Dr. Francis Collins on Ebola. So I have added my 2 cents – lets see if it gets accepted and a response from some moderator (..Tax dollars well spent – who would want that job responding to folks like me). There are plenty of smart …

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Oct
02

A pharmacophore for compounds active against Ebola

I was looking through Pubmed yesterday looking for repurposing efforts applied to Ebola and found the paper by Madrid et al. This described many hits, including chloroquine and amodiaquine. Then I was tweeting with@DokteCoffee last night and she suggested another paper by Johansen et al., which described SERMs such as clomifene andĀ  toremifene. Interestingly Madrid …

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