A couple of weeks ago I was in Denver for the AAPS2016 meeting. This was the first time I had been at the meeting in quite a number of years and there were some changes. Firstly posters were now electronic and that did not seem a positive change for me. The loss of something to …
Category Archive: science communication
Nov
29
Nov
14
Leaving the nest – Looking for start-up co-working and incubator space
I have worked from home for the better part of a decade either from my past location in PA or my present location in NC. Thanks to getting a recent grant, I now need to hire a postdoc and that means I can fly the nest (which in my case is my home). But with …
Sep
20
Progress Through Partnership: The NINDS 2016 Nonprofit Forum
Last tuesday and wednesday (Sept 13-14th) I was very honored to be an attendee at the “Progress Through Partnership: The NINDS 2016 Nonprofit Forum“. My role was to provide an industry perspective on several panels (alongside Dr. Ronald Marcus, Cerecor). There were a large number of rare disease (patients or parent) advocates, academic scientists and …
May
23
France faults Bial and Biotrial over fatal drug trial – but what caused it?
New posts appeared yesterday and today on the Bial drug (Bial 10-2474) failure in France. What follows is the Google translate of this article in Le Figaro “Biotrial the laboratory, who led the fatal clinical trial in Rennes, committed “three major shortcomings,” the final report of the General Inspectorate of Social Affairs (IGAS), animal health, …
Mar
16
Why this may be my last ACS
For many the ACS is the one meeting they go to year in year out. Me too. On and off over approximately 16 years I have attended with a poster or given talks and even done booth duty. But the current meeting in San Diego may well be my last. Monday I gave a couple of …
Feb
16
An illustration of the virus and summary of Research Priorities to Inform Public Health and Medical Practice for Domestic Zika Virus: A Workshop
Late last week I was contacted by John Liebler a science and medicine illustrator and he had seen the Zika glycoprotein E homology model and wanted to use it to produce an image of the virus. After reading up on flaviviruses it appeared to me that the original model was of the trimer and not …
Jan
21
Differences between similar FAAH inhibitors and their in silico target predictions
**UPDATE As of 21st Jan 2016 please note the actual structure of BIA 10-2474 changed to this. The continuing follow up to the clinical trial disaster. Chris Southan yesterday suggested I try CID 57880883 as the comparator to CID 54576693 (JNJ-42165279). These have IC50 75 nM vs 350 nM, respectively according to Jannsen’s WO2011139951. Yesterday …
Jan
20
Where will BIA 10-2474 lead us?
**UPDATE As of 21st Jan 2016 please note the actual structure of BIA 10-2474 changed to this. My “Armchair science” / speculative contributions on this blog for the clinical trial disaster with BIA 10-2474 got a bit of notice over the past few days at Forbes and C&E News. There have also been discussions with …
Jan
15
ACS San Diego Talks
My schedule for the ACS in San Diego came through today – if you want to catchup please get in touch! PAPER ID: 2393678 PAPER TITLE: Virtual collaborations for developing Sanfilippo syndrome treatments on a shoestring (final paper number: SCHB 5) DIVISION: Division of Small Chemical Businesses SESSION: Start-up Businesses in Drug Discovery SESSION TIME: …
Jan
06
Select antimalarials saved lives of those infected with Ebola Virus
Lets start 2016 with a bang. Frequent Ebola collaborator Dr. Megan Coffee just pointed me to a new article in the New England Journal of Medicine that showed a ‘natural experiment’ of how fewer Ebola patients died if treated with artesunate-amodiaquine compared with artemether-lumefantrine. This is fascinating because it goes some way to verify work …
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