Category Archive: repurposing

Nov
29

AAPS 2016

A couple of weeks ago I was in Denver for the AAPS2016 meeting. This was the first time I had been at the meeting in quite a number of years and there were some changes. Firstly posters were now electronic and that did not seem a positive change for me. The loss of something to …

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Feb
03

A Zika drug discovery collaboration

Today a nice collaboration has lead to submission of an opinion article to F1000Research. As an experiment I have posted the manuscript and some of the supplemental data online at FigShare. I hope to add more as time permits. This is definitely a work in progress. This project has consumed lots of time from all …

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Jan
26

Creating a rapid response – relevant to Zika virus

I have been following the news on the Zika virus over the last few weeks as it has spread with travelers returning from trips and women giving birth to children with microcephaly. Along with it is a spreading underlying fear of where it will lead. Its not so long ago that Ebola, was grabbing headlines. …

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Jun
26

Viva Collaboration! A new paper in a PLOS journal – and epic responses to reviewers

I am excited to say our new paper on Chagas Disease┬ájust published in PLOS Neglected Tropical Diseases. This was a relatively painless process compared to previous PLOS experiences. We submitted March 31, had reviews back by May 8th and the paper was finally accepted June 5th after some back and forth. We did have some …

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May
01

The next generation of Tuberculosis researchers

I like to help and mentor students in various ways when I can. Over the years this has lead to some fun projects and computational models. For a long time I have been an Adjunct Associate Professor at the University of Maryland, yet today I heard about a group of undergraduates there working on Tuberculosis. …

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Oct
20

In response to the NIH director

I just found a post by Dr. Antony Fauci and Dr. Francis Collins on Ebola. So I have added my 2 cents – lets see if it gets accepted and a response from some moderator (..Tax dollars well spent – who would want that job responding to folks like me). There are plenty of smart …

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Oct
08

Where is the big Pharma Knight riding in to slay Ebola?

In full disclosure my better half works for a big pharma, this is not going to hold me back from writing what I am sure everyone is thinking. It saddens me as someone who worked for big pharma (until 2001) to have to write this. We are months into the rapidly escalating catastrophe that is …

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Jan
23

The Non-Drowsy Chaperone

Digging through the recent literature for lysosomal diseases, something caught my attention. I have a bit of an interest in following the progress in finding chaperones for diseases like Sanfilippo syndrome and others. Chaperones are primarily small molecules that may help a protein fold and stabilize it. I first became aware of this when I …

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Jan
21

Done multitargeting, how about multidiseasing?

When we think of drugs used for more than one different disease (e.g. a drug that’s not just used for 2 different cancers) we can probably list them on one hand. These are usually the result of a happy coincidence or happy experiment more likely. We can call it repurposing. Repositioning, rebranding, reuse or whatever.. …

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Dec
30

Summary of collaborative publications in 2013.

Time for a brief end of year summary and some insights into various papers, reviews and commentaries I was involved in this year. I have probably missed a few papers that are either not in PubMed or come to mind readily so will likely add as I remember them. What really struck me in a …

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