*(Well maybe for Tuberculosis, Malaria, Huntington’s disease, HIV/AIDS, Chagas Disease, Leishmaniasis, Hunter syndrome, Giant Axonal Neuropathy, H5N1, Fibromusclar Dysplasia, Sanfilippo Syndrome etc) Helping collaborators with their NIH grants (R01, U19, SBIR, STTR, etc.), one is struck by something that has to be done early in most cases yet is usually left till last. That is …
Category Archive: Open Data
Mar
14
Why are papers on rare diseases from the FDA and NIH behind journal paywalls?
Hypothetically, lets just ask the question what would you do if you, a family member or a friend was diagnosed with a rare disease.. what would you do? If there was no cure where would the first place be that you would look for guidance? Wikipedia, Google probably would be first then these would point …
Feb
12
A new start- one conference at a time
Once you meet someone at a conference (or perhaps under other circumstances too) the experience can potentially change what you do. Yes I actually wrote that, from personal experience. What I had not expected was that this can happen over and over again. Is it because I am particularly receptive or malleable? I do not think …
Feb
02
Science Online day 2 Hip Hop and day 3 Health apps
“New York, New York, Big city of dreams, everything in New York ain’t always what it seems” – Melle Mel ..circa 1980’s rewind…that should be “Raleigh. Raleigh, Big city of science, Everthing at scio13, aint always what it seems” Who needs to go to the big Apple or some other metropolis for a …
Jan
31
Science Online 2013 – day 1 – keeps surprising me
What a day..I should say that a terrific storm last night contributed substantially to the exhaustion I am feeling as I write this so I will keep it short and expand more fully in future blogs. But I have to get my thoughts down as I filter my experiences through what I heard and said …
Jan
30
Why we need Collaborative Drug Discovery
Lets get this out of the way before I start. Collaborative Drug Discovery is something that is very important to me. I am passionate about it. Predominantly because it has collaboration at the core and if we could all do more of this I think we could impact finding cures for so many diseases, neglected and …
Jan
29
Preparing for Leading scientists towards openness
Since Antony Williams has introduced us as moderating a session at Science Online 2013 here are some more thoughts to get ideas going and some insight. Some slides to get you thinking and stoke discussion are here . Firstly why are we doing this? Last year there was some great discussion on open notebook science …
Jan
23
Using TB Mobile to Predict Potential Targets for TB hits from Phenotypic Screening
Sometimes there is a beautiful timing in how things arrive in the literature. For instance with my collaborative work for CDD I have been writing manuscripts on how we can use machine learning models to predict likely actives in whole cell phenotypic screens for M. tuberculosis. I have tested these models, retrospectively, prospectively, within the same lab, …
Nov
09
I have seen the future – Solutions are more newsworthy than problems
A small thought has been burning away inside..I like many am profoundly interested in the future and in finding solutions to problems. This predominantly happens through collaboration. Collaboration which is a 2 way process. At the moment based on what makes news, developing solutions and solving problems is hardly news worthy. I have mentioned before how we and …
Oct
26
NCATS Repurposing – paper in press and molecules tweeted
From past blogs I have detailed The NCATS library of industry Provided reagents. Through the heroic collaborative efforts of Dr. Chris Southan and Dr. Antony Williams we now have the structures for most of the NCATS and MRC molecules described in a paper in press. In addition the molecules sourced to date have just been …
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