Category Archive: HTS


Nobel prize in medicine – going back to natural products for drugs

Every year there are potentially 1000’s of scientists that could have won the Nobel prize and did not. This year the prize recognizes 3 scientists for their work on parasitic diseases.¬† William Campbell¬† and Satoshi Omura won for their work on discovering Avermectin which lead to treatments for River Blindness and Lymphatic Filariasis. Youyou Tu …

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Finally after 18 years – Time for a Research Statement

Its been something I continually grapple with. As a non academic doing a diverse range of scientific projects how could I come up with a vision statement (if indeed I needed one as I have managed for 18 years without one). A few days ago I put a research statement together. I think it basically …

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Predicting Targets for TB Phenotypic Screening Hits and Openess of data and models

So far the only readily accessible, free approach to predicting TB targets is TB Mobile developed for iOS and Android with Alex Clark. While relatively crude the app does allow look up and similarity searching of 745 compounds with known targets so it may help propose possible targets for a new compound. Obviously there are …

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Dispensing paper – many views but what about impact?

Back in early May the paper with Joe Olechno and Antony Williams was published in PLOS ONE and got a bit of exposure. This lead to a few posts here and elsewhere as it got picked up by others. My absence from this forum / outlet for a few months has enabled a bit more …

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Curiosity, Science, HTS and is newer really better?

I have been a humble participant in several discussions in the last few weeks that have been stimulated by the paper on dispensing and IC50 differences between pipette tips and acoustic handling. I am still parsing them, but what really stands out is the complete lack of exhaustive comparisons in academic screening centers between different …

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Greater than the sum of the parts – issues in drug discovery

Inspired by the years of reading and also recent collaborative forays into the complexity of data quality and tools used for dispensing in HTS I have started to list issues that we need to be aware of in drug discovery (“anything that can go wrong – which will go wrong”). 1. How you move liquids …

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