Category Archive: Getting America to work

Jan
30

Pharma Vulnerability Index

After yesterdays post about the closing of the AZ site in Bangalore and a few Tweets with Peter Kenny and Derek Lowe about the vulnerability of anyone working in big pharma, I was mulling who would be next. Its hideously sad, but the reality is no site appears safe. For example in recent years – …

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Jan
20

Thrifty computational science

Can we be thrifty and still do good science? We demand more. For example why validate a model with 20 compounds when you could use 10? It’s all about statistics and power, but really do we over do it. For example from experience grant reviewers want to see you compare other machine learning models, even …

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Jan
15

Back seat science reading

On the return flight on Monday not only did I have time to write a post, I also found inspiration for this one too. Expecting to find the airline magazine in the back pocket of the seat, I instead discovered the Jan 6th issue of the THE NEW YORKER. Some very kind person had left …

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Jan
13

Rekindling that dream job fantasy in science

What would be your ideal job? “Good question” you answer, “not now, I am thinking”, “I already have it”. Do any of these responses fit the bill? Often wondered what that dream job would be? Have you daydreamed in those idle moments, over coffee, beer, or some other tasty beverage? Perhaps you would fantasize about …

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Jun
27

Hiring a postdoc (applied computational chemistry)

As I may have mentioned before I have a long time TB collaboration with Dr. Joel Freundlich at UMDNJ, Newark (soon to be Rutgers). Over the past few years this has lead to some papers with collaborators on: 1) TB metabolite mimicry – Sarker, M. et al., “Combining Cheminformatics Methods and Pathway Analysis to Identify …

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May
13

Rare diseases make it into Chemical and Engineering News – chemists can help !

I want to take some time to highlight a terrific 4 part article  “Orphans find a home” that came out today in Chemical and Engineering News by Lisa Jarvis which I think absolutely captures what I have been seeing the last few years through my interactions with several rare and ultra rare disease groups – or fighter …

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Oct
11

Jim Gray eScience Award from Microsoft Research goes to “a doer”

Occasionally you meet really, really awesome people that confirm that life is worth all the junk we put up with 99% of the time. A few years ago (2007)  I was introduced to a database that has had a huge impact on me and probably thousands of others..That database, ChemSpider started life in a garage not …

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Mar
20

Drug Discovery in LA or NC..Location, Location, Location (Does it matter?)

Ah, for those moments when your mind just drifts off (for a millisecond) and you think what other wonderful opportunities there are out in the real world for careers in our strange pharma/ biotech industry…you have to hand it to the automated recruiter emails for entertainment value (far more interesting than the spam conferences in China with …

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Oct
28

A golden opportunity for open science

I give a few talks to different kinds of scientific audiences, and it is always important that I feel a passion for the subject that I can bring over. Last week I had the opportunity to talk to many IT decision makers at global drug companies about collaboration. Today I gave an invited co-presentation (with Antony …

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May
10

Repurposing medicinal chemists…to clean up chemistry databases

Late last year around the time of the ACS conference in Boston I was mulling what could be done with all the chemists being laid off by pharma. One thought was one of the non profits working on neglected diseases could put them to work. But I hear you say well EVERYONE is outsourcing chemistry …

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