I just read the commentary by Francis Collins and Lawrence Tabak in Nature re: reproducibility. As we have pointed out before, its possible the NIH should look closer to home for data quality issues. Reproducibility is important, but the databases NIH creates and funds will reach more people and have more impact on science, so …
Category Archive: data quality
Dec
30
Journal editors add more balance than needed – provides marketing windfall
Just when you think the year is going to end without having to get drawn into some additional discussion on publishing.. well it happens.. I get an email today that the article a (very nice) journalist, Vivien Marx had written for Nature Methods “Pouring over liquid handling” was now published. Lets get this straight at …
Dec
06
Dispensing paper – many views but what about impact?
Back in early May the paper with Joe Olechno and Antony Williams was published in PLOS ONE and got a bit of exposure. This lead to a few posts here and elsewhere as it got picked up by others. My absence from this forum / outlet for a few months has enabled a bit more …
Aug
16
Finding invisible neglected TB in vivo active compounds with ChemSpider
Very occasionally I come across molecules that cause me to scratch my head and do a double take. I frequently scour databases to find obscure ones to build structure activity relationships or try to learn from the past. Sometimes you uncover surprises along the way – or in one case, many . 24hrs ago I …
Jul
31
Curiosity, Science, HTS and is newer really better?
I have been a humble participant in several discussions in the last few weeks that have been stimulated by the paper on dispensing and IC50 differences between pipette tips and acoustic handling. I am still parsing them, but what really stands out is the complete lack of exhaustive comparisons in academic screening centers between different …
Jul
22
Data Accessibility in the 21st Century
I was reminded at the weekend that there are are accessible scientists and there is accessible data and occasionally both. I recently had a reprint request for a paper I co-authored in 1999 and a dataset request for a paper published in 2010. I took time out of my weekend to respond to both scientists …
Jul
11
Greater than the sum of the parts – issues in drug discovery
Inspired by the years of reading and also recent collaborative forays into the complexity of data quality and tools used for dispensing in HTS I have started to list issues that we need to be aware of in drug discovery (“anything that can go wrong – which will go wrong”). 1. How you move liquids …
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