New posts appeared yesterday and today on the Bial drug (Bial 10-2474) failure in France. What follows is the Google translate of this article in Le Figaro “Biotrial the laboratory, who led the fatal clinical trial in Rennes, committed “three major shortcomings,” the final report of the General Inspectorate of Social Affairs (IGAS), animal health, …
Category Archive: closing gate after horse has bolted
Apr
20
Final report of CSST on BIA 10-2474 tragedy
I took the report released yesterday by ANSM on BIA 10-2474 and Google translated the whole doc.. Its not perfect but here goes. All the usual caveats apply – that its far from a perfect job but should provide the key points. Would be great to get an official translation at some point. I find …
Apr
19
Another tragedy – BIA 10-2474 – yes its toxic after 600hrs of committee deliberations
Wow what an anticlimax.. Months after the tragic death in January of a clinical trial volunteer, the medical experts (CSST) in France have declared BIA 10-2474, the experimental drug administered was the problem. It has to to be read to be believed. I bet you could have picked anyone off the street and presented with …
Apr
13
BIA 10-2474 saga continues – who knew what and when – and nobody comes out a winner
Apologies, recovering from some bug and my head is a bit fuzzier than usual so I hope this all makes sense. A day that started surreal and just kept going. Straight out of the gate this morning I had an email from a journalist Damien Mascret from Le Figaro. I had never been in contact …
Jan
19
Using more online software to make predictions for BIA 10-2474
**UPDATE As of 21st Jan 2016 please note the actual structure of BIA 10-2474 changed to this. To continue the theme of the last few posts on the BIA 10-2474 compound in which I have used over 2000 Bayesian models and an App as well as another groups target prediction tool. To take this …
Jul
21
Wiki, Wiki, Wiki – for chemical probes
Sorry for the cheap title (for those born after the mid 80’s its a reference to a song by a funk band called Newcleus). A very interesting commentary published today in Nature Chemical Biology by Arrowsmith et al and its all about chemical probes. Go check it out and note that it took over 50 …
Mar
22
What warrants an erratum and why the old publishing model must change
Friday AM my day started with an email which I have marked up and added links to Dear Dr. Ekins: It has come to our attention that an error was identified in your recent Perspective entitled “The parallel worlds of public and commercial bioactive chemistry data” published in the March 12, 2015 issue of the …
Aug
11
ACS in San Francisco..6 talks and a poster
For a few days I am in SF presenting several talks ..In all but one case I plan to post the talks.. Yesterday’s talk was on collaborations. The prior speaker did not turn up so I gave it twice. Today I gave two presentations. One on TB mimics. This work is subject to some papers …
Jan
31
How to create a Pharma Vulnerability Index (PVI)
Yesterday I think I hit a nerve and may have kick started one of the book projects laying dormant . My gut feelings based on recent observation lead to proposing a Pharma Vulnerability Index. I just threw it out there. pretty sure that anyone who follows big pharma stock as a job or hobby probably …
Jan
30
Pharma Vulnerability Index
After yesterdays post about the closing of the AZ site in Bangalore and a few Tweets with Peter Kenny and Derek Lowe about the vulnerability of anyone working in big pharma, I was mulling who would be next. Its hideously sad, but the reality is no site appears safe. For example in recent years – …
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