Category Archive: biography

Jan
13

Rekindling that dream job fantasy in science

What would be your ideal job? “Good question” you answer, “not now, I am thinking”, “I already have it”. Do any of these responses fit the bill? Often wondered what that dream job would be? Have you daydreamed in those idle moments, over coffee, beer, or some other tasty beverage? Perhaps you would fantasize about …

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Jan
10

Working at the peripheries of science

Its Friday, the first full week back at work for 2014 and I am already pondering, (well mulling really) why I still do what I do. And the constant media attention for youth and success just needles me, especially for those in science. Yes I said goodbye to 30 a longtime ago, 40 a few …

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Jan
07

A new year and a New start – leaving the Pistoia Alliance Board of Directors

I hope I can say 2014 is a New Start. Due to my increase in time contributed to working on rare diseases through Jonah’s Just Begun, the Hereditary Neuropathy Foundation and Hannah’s Hope Fund my “free time” has taken a bit of a squeeze. In addition when combined with the 3 NIH grants I am …

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Jan
06

Why I passed on attending #scio14

For the last 2 years I have been incredibly fortunate to attend and participate in what I think is the best conference ever, namely Science Online. Antony Williams introduced me to this conference and we had a great time discussing ideas each year I attended. The format and topics of discussion were excellent and they …

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Dec
30

Summary of collaborative publications in 2013.

Time for a brief end of year summary and some insights into various papers, reviews and commentaries I was involved in this year. I have probably missed a few papers that are either not in PubMed or come to mind readily so will likely add as I remember them. What really struck me in a …

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Jul
12

Crazy editorial control at ResearchGate

Some things just really annoy me to the point that I write them up as posts. This one is no exception. After literally hundreds of ‘spam’ emails in recent weeks from ResearchGate I felt the “pressure ” to actually look at the product and try to update it with my profile and papers etc..just in …

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Jul
11

Greater than the sum of the parts – issues in drug discovery

Inspired by the years of reading and also recent collaborative forays into the complexity of data quality and tools used for dispensing in HTS I have started to list issues that we need to be aware of in drug discovery (“anything that can go wrong – which will go wrong”). 1. How you move liquids …

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Jun
27

Hiring a postdoc (applied computational chemistry)

As I may have mentioned before I have a long time TB collaboration with Dr. Joel Freundlich at UMDNJ, Newark (soon to be Rutgers). Over the past few years this has lead to some papers with collaborators on: 1) TB metabolite mimicry – Sarker, M. et al., “Combining Cheminformatics Methods and Pathway Analysis to Identify …

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Jun
04

Pharmacophore Q&A inspired by Charles Eames

I have been using pharmacophores as part of my research since 1996 for everything from enzymes, transporters and complex data. I figured this topic was long overdue for some sort of compilation. Having recently watched a short film/slide show by Charles Eames in which he gave a short Q&A on design I too was inspired …

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May
13

A virtuous cycle

Since publishing a couple of papers in PLOS ONE (here and here) over the past few weeks and my respective blogs (here, here, here and here) there seems to be more interest than usual on this blog and much of this has been driven by attention from Derek Lowe’s In the Pipeline blog. I have summarized …

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