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  • A Rare Breed

    I have been doing a lot of reading lately after a period last year when I did not touch a book. Mostly these books are related to science and published in the last year and I am devouring them at a rate of one per week or two. A recent one was very compelling and …

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  • Voucher roller coaster ride

    Its been a while since my last post here but its getting harder to find time between the 2 companies and writing grants. But one of the most interesting things I have been watching has been the roller coaster ride of the Pediatric Rare Disease priority review vouchers over a few years. The most recent …

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  • Getting to an in vivo active compound

    Its been an incredibly fast paced year and hence my posting frequency has suffered. Perhaps its time to get back to writing . Today we had a press release with SRI so that triggered me to fill in the back story. Rewind back to 2014 and the Ebola outbreak was in full flow – see …

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  • Seeing through the hype of deep learning for drug discovery

    The frequency seems to be increasing where I see something that sets me off (head in hands saying why, why why?)..Over the past few years I have seen AI/ Deep Learning and drug discovery appearing often and that may not be a good thing. Now this could be the PR engines of the VC’s, companies …

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  • A Dying Breed

    If you have ever wondered how the pill you are taking for your disease originated, then nowadays you don’t have to go far to find out, as a quick search of Wikipedia will return the molecule, who makes it, and a wide array of prescribing information and warnings. This has not always been the case, …

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  • Summer intern for Collaborations Pharmaceuticals

    We are seeking a Biochemist or Chemist (Masters/PhD) for a summer intern assignment in our Raleigh NC offices.  The duties of the scientist will be to assist with expert data curation for computational modelling of rare and neglected diseases. This position is ideal for a Masters or PhD student in the RTP or Triad area …

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  • Drug Discovery Today Special Issue on Tuberculosis

    Today a special issue of Drug Today Today was published. I was  the editor of this issue and honored that so many colleagues from our European funded MM4TB and other European projects agreed to provide articles on their contributions to Tuberculosis drug discovery. Through collaborations I was directly involved in providing 3 articles and an …

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  • A bit of an update on Collaborations Pharmaceuticals

    Its been a few months since the last post. In that time Collaborations Pharmaceuticals has been working flat out. We hired a Postdoc and associate and have been keeping our heads down working on the 3 NIH grants with collaborators. Next week I will be representing the team at the Gordon Conference on Tropical infectious diseases and …

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  • Post doctoral position on chaperone development for neurological disorders

    I would like to highlight an open postdoc position in the lab of a close collaborator Dr. Alexey Pshezhetsky Open position: Postdoctoral fellow or Ph.D. student Supervising researcher and laboratory: Dr. Alexey Pshezhetsky, laboratory studying lysosomal biology and metabolic disorders, Research Center of CHU Sainte-Justine Project length: 1 year with renewal opportunity Start date: Immediately …

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  • Small Molecule Bioactivity Databases Book Chapter

    Its been a busy year transitioning from spending most of my time with CDD to my start-up Collaborations Pharmaceuticals, Inc etc. Along the way I found time to write a few book chapters. One of these recently published in High Throughput Screening Methods : Evolution and Refinement Editors: Joshua A Bittker, Nathan T Ross Our …

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